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  • Title: Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein.
    Author: Gery I, Wiggert B, Redmond TM, Kuwabara T, Crawford MA, Vistica BP, Chader GJ.
    Journal: Invest Ophthalmol Vis Sci; 1986 Aug; 27(8):1296-300. PubMed ID: 3488297.
    Abstract:
    Rats immunized with microgram amounts of interphotoreceptor retinoid-binding protein (IRBP), a glycoprotein which localizes specifically in the eye and pineal gland, developed uveoretinitis and pinealitis. The severity and onset of changes were found to be dose-related and to be enhanced by B. pertussis bacteria. In general, the inflammatory changes induced by IRBP resembled those provoked by S-antigen (S-Ag), but significant differences were noted between the two diseases. The possible usefulness of the new experimental autoimmune disease is discussed.
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