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  • Title: An Easy Route to Aziridine Ketones and Carbinols.
    Author: Strumfs B, Hermane J, Belyakov S, Sobolevs A, Velikijs K, Uljanovs R, Trapencieris P, Strumfa I.
    Journal: Int J Mol Sci; 2021 Dec 05; 22(23):. PubMed ID: 34884949.
    Abstract:
    N,N-Dimethylaziridine-2-carboxamides react with organolithium reagents yielding 2-aziridinylketones. The reaction with one equivalent of organolithium compound is selective to amide carbonyl at a low (-78 °C) temperature. These ketones, in reaction with organolithium reagents, give symmetrical and unsymmetrical aziridinyl carbinols. The usage of excess phenyllithium may serve as a special N-Boc-protecting group cleavage method for acid-sensitive substrates.
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