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  • Title: Analgesic and anti-inflammatory activity of 10-amino-11H-indeno [1,2-b] quinolin-11-one derivatives.
    Author: Bała M, Naparzewska A, Chojnacka-Wójcik E.
    Journal: Pol J Pharmacol Pharm; 1986; 38(2):221-7. PubMed ID: 3489228.
    Abstract:
    Ten novel derivatives of 11H-indeno [1,2-b] quinolin-11-one (1-10) were synthesized and pharmacologically screened. All compounds showed analgesic activity. Anti-inflammatory activity was found only for alkylamine derivatives 1-6. The most active 10-ethylamine derivative 2 showed also ulcerogenic properties. The LD50/UD50 and UD50/ED50 values for compound 2 were less satisfactory than those for ibuprofen.
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