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  • Title: Anthraquinones with potential antiproliferative activities from the fruits of Morinda citrifolia.
    Author: Shen ZY, Zhao YY, Qiao ZH, Xie Z, Guan RQ, Liu ZY, Liu YP, Chen GY, Fu YH.
    Journal: Nat Prod Res; 2023 May; 37(9):1456-1462. PubMed ID: 34894893.
    Abstract:
    The phytochemical investigation on the fruits of Morinda citrifolia led to the isolation and characterization of a new anthraquinone, moricitrifone (1), along with seven known anthraquinones (2-8). The chemical structure of 1 was elucidated by extensive spectral analyses. The known compounds (2-8) were identified by comparing their spectral data with those reported in the literature. The antiproliferative activities of all isolated anthraquinones (1-8) against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 were evaluated in vitro. Compounds 1-8 exhibited remarkable antiproliferative activities with IC50 values ranging from 0.26 ± 0.05 to 16.58 ± 0.18 μM, which were comparable to those of doxorubicin.
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