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  • Title: [Cell-mediated immunity in patients with atopic allergic diseases].
    Author: Kosturkov G, Bozhkov B, Savov S, Dimitrov V.
    Journal: Vutr Boles; 1986; 25(4):60-6. PubMed ID: 3490058.
    Abstract:
    Some parameters of cellular-mediated immunity in patients with atopic bronchial asthma and pollinosis rhinitis were studied. A statistically significant reduction of suppressor and active subpopulation was established as well as of the total fraction T-lymphocytes and a growth in the helper-suppressor ratio. A statistically significant reduction of lymphocytic reactivity to phytohemagglutinins was also established via blasttransformation test as compared with a group of healthy subjects. The results obtained convincingly confirmed a quantitative and functional T-cellular immunodeficiency in atopy. The clinical improvement of the patients with atopic bronchial asthma that were conducted a specific hyposensibilization for over 6 months, was accompanied by increase of T-suppressors and active T-cells and reduction of immuno-regulatory index. Some practical trends in the early diagnosis of immunodeficient state in atopic diseases are discussed.
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