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  • Title: An epidermal factor which induces thyroid hormone-dependent regression of mesenchymal tissues of the tadpole tail.
    Author: Niki K, Yoshizato K.
    Journal: Dev Biol; 1986 Nov; 118(1):306-8. PubMed ID: 3490413.
    Abstract:
    Explants of tadpole tail skin secreted a factor which induces the thyroid hormone-dependent regression of the tail mesenchyme. The activity of the factor was not sensitive to digestion with trypsin or pronase. Heating at 120 degrees C but not at 100 degrees C for 20 min destroyed the activity. The factor came out gradually through a dialysis membrane. The factor was retarded on a Sephadex G-10 column and eluted with water after the salts fraction. We suggest that the active principle is a non-proteinaceous substance with a low molecular weight.
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