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  • Title: A simple hydrazone probe for recognition of Al3+ and PPi and its applicability in lysosomal imaging.
    Author: Song YF, Cai HX, Wu WN, Zong HT, Li M, Wang Y, Fan YC, Xu ZH.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2022 Mar 05; 268():120680. PubMed ID: 34906844.
    Abstract:
    A simple hydrazone probe (1) was designed and synthesized for the successive detection of Al3+ and pyrophosphate (PPi) in almost 100% buffer environment. The probe provided O2N donor set for chelation with Al3+, leading to a distinct fluorescence boost at 510 nm. The in-situ formed 1-Al3+ complex detected PPi with an "on-off" behavior. The detection limits for Al3+ and PPi were 35.7 nM and 76 nM, respectively. Benefiting from the existence of morpholine as lysosome-targeting group, probe 1 was successfully applied to the detection of Al3+ and PPi in lysosomes.
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