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  • Title: Effect of T-lymphocyte suppression on the parasite burden in Leishmania major-infected, genetically susceptible BALB/c mice.
    Author: Solbach W, Forberg K, Röllinghoff M.
    Journal: Infect Immun; 1986 Dec; 54(3):909-12. PubMed ID: 3491051.
    Abstract:
    Treatment of Leishmania major-infected, genetically susceptible BALB/c mice with the T-lymphocyte-immunosuppressive drug cyclosporin A (CyA) resulted in a significantly reduced parasite burden in the local site of infection and in the draining lymph nodes. These data indicate that T cells are pivotal for the propagation of L. major in vivo.
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