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  • Title: Comparison of induction characteristics of four intravenous anaesthetic agents.
    Author: McCollum JS, Dundee JW.
    Journal: Anaesthesia; 1986 Oct; 41(10):995-1000. PubMed ID: 3491551.
    Abstract:
    The induction characteristics of thiopentone, etomidate and methohexitone have been compared to those of propofol (2,6 di-isopropyl phenol) in unpremedicated patients. Propofol 2.5 mg/kg caused significantly more hypotension, excitatory side effects and pain on injection at the dorsum of hand than thiopentone 5 mg/kg. However, with regard to the latter two sequelae, etomidate 0.3 mg/kg and methohexitone 1.5 mg/kg caused similar or more frequent upset. Propofol 2.0 mg/kg was equipotent with thiopentone 4.0 mg/kg in terms of successful induction of anaesthesia. Hypotension may contraindicate the use of propofol in the hypovolaemic or unfit patient.
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