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  • Title: Megaloblastic bone marrow changes after repeated nitrous oxide anaesthesia. Reversal with folinic acid.
    Author: Nunn JF, Chanarin I, Tanner AG, Owen ER.
    Journal: Br J Anaesth; 1986 Dec; 58(12):1469-70. PubMed ID: 3491617.
    Abstract:
    A seriously ill patient was found to have megaloblastic changes in his bone marrow after a nitrous oxide anaesthesia which lasted for 105 min. After an interval of 7 h a second nitrous oxide anaesthetic was administered, during which the patient received 30 mg of folinic acid. His marrow was normal when assessed 4 h later.
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