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  • Title: [Morphological and immunologic changes following intratumoral administration of alpha interferon in patients with breast cancer].
    Author: Polevaia EB, Ermilova VD, Kupin VI.
    Journal: Vopr Onkol; 1986; 32(12):19-23. PubMed ID: 3492075.
    Abstract:
    Patients with early breast cancer received single intratumoral injections of 10,000, 100,000 or 200,000 IU alpha-interferon before radical surgery. Interferon was found to produce a dose-dependent cytotoxic and immune-boosting effect. A dose of 100,000 and 200,000 IU caused drug pathomorphosis in tumor and brought down immunologic indexes of peripheral blood. Administration of 10,000 IU stimulated T-cell-mediated immunity.
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