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  • Title: Antimicrobial lanostane triterpenoids from the fruiting bodies of Ganoderma applanatum.
    Author: Shi JX, Chen GY, Sun Q, Meng SY, Chi WQ.
    Journal: J Asian Nat Prod Res; 2022 Nov; 24(11):1001-1007. PubMed ID: 34923886.
    Abstract:
    A chemical investigation on the 90% EtOH extract of the fruiting bodies of Ganoderma applanatum led to the isolation of three new lanostane triterpenoids, designated as 25-methoxy-11-oxo-ganoderiol D (1), 3-oxo-25-methoxy-24,26-dihydroxy-lanosta-7,9(11)-diene (2), and 3β-acetyloxy-lucidone H (3). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their antimicrobial activities against six pathogenic microorganisms. Compounds 1 and 2 exhibited some activities against three Gram positive bacteria with MIC values less than 60 μg/ml.
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