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  • Title: Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis.
    Author: Odum N, Morling N, Friis J, Heilmann C, Hyldig-Nielsen JJ, Jakobsen BK, Pedersen FK, Platz P, Ryder LP, Svejgaard A.
    Journal: Tissue Antigens; 1986 Oct; 28(4):245-50. PubMed ID: 3492783.
    Abstract:
    Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.
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