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  • Title: An antiviral T-cell clone defines a functional supertypic specificity shared by different HLA-DR molecules from DR2-short, DRw11, and DRw13 haplotypes.
    Author: Zeliszewski D, Sterkers G, Choppin J, Freidel C, Gebuhrer L, Betuel H, Levy JP.
    Journal: Immunogenetics; 1987; 25(2):84-90. PubMed ID: 3493215.
    Abstract:
    An influenza virus-specific HLA class II-restricted human T4+ clone (Ij) allows us to define a new functional supertypic HLA class II specificity shared by three different haplotypes. Influenza A virus-infected antigen-presenting cells of these three haplotypes, HLA-DR2 short, DRw11, and DRw13, are able to stimulate Ij cells. The same precise viral specificity is seen in all three cases. Proliferation inhibition experiments using HLA-specific monoclonal antibodies demonstrate that HLA-DR products are involved in all cases. However, according to the DR specificity of the antigen-presenting cell, differential blockings by a series of DR-specific monoclonal antibodies suggest that the functional epitope is shared by different HLA-DR molecules. This is confirmed by two-dimensional gel analysis of the HLA-DR beta chains expressed in the three haplotypes.
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