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  • Title: Estrogen binding sites in peripheral blood mononuclear cells and thymocytes from 2 myasthenia gravis patients.
    Author: Carbone A, Piantelli M, Musiani P, Larocca LM, Aiello FB, Maggiano N, Scoppetta C, Crucitti F, Ranelletti FO.
    Journal: J Clin Lab Immunol; 1986 Oct; 21(2):87-91. PubMed ID: 3493349.
    Abstract:
    In the present investigation the estrogen binding capacity of peripheral blood mononuclear cells (PBMC) and thymocytes from 2 young female Myasthenia Gravis (MG) patients has been studied. We found high levels of estrogen binding sites in both pre-thymectomy PBMC and lymphoid cells from the hyperplastic thymuses of the MG patients. A sucrose density gradient analysis revealed that the estrogen was binding to macromolecular species similar to those characterized in cytosols from classical estrogen target organs. A post-thymectomy time-dependent decrease of the estrogen binding capacity was also observed in PBMC, reaching levels similar to that of sex- and age-matched controls.
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