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Title: [Acupoint thread-embedding as adjuvant therapy for bronchial asthma in children and its effect on pulmonary function, serum IgA and IgE levels].
Author: Yang YF, Wang XY, Kong LX, Zhang YM, Zhao L.
Journal: Zhongguo Zhen Jiu; 2021 Dec 12; 41(12):1349-53. PubMed ID: 34936273.
Abstract:
OBJECTIVE: To observe the efficacy of acupoint thread-embedding combined with fluticasone propionate aerosol for chronic persistent bronchial asthma of lung-spleen qi deficiency and spleen-kidney yang deficiency in children and its effect on pulmonary function and serum levels of IgA and IgE. METHODS: A total of 120 children with chronic persistent bronchial asthma were randomly divided into an observation group (60 cases, 9 cases dropped off) and a control group (60 cases, 7 cases dropped off). The control group was treated with fluticasone propionate aerosol (125 μg per inhalation), twice a day; based on the control group treatment, the observation group was treated with acupoint thread-embedding at Dingchuan (EX-B 1), Feishu (BL 13), Zusanli (ST 36) and Danzhong (CV 17), once half a month. Both groups were treated for 3 months. The pulmonary function, serum IgA, IgE levels and TCM symptom score were compared between the two groups before and after treatment, and the clinical efficacy was evaluated. RESULTS: After treatment, the large airway function (peak expiratory flow [PEF], forced expiratory volume at the first second [FEV1]) and small airway function (maximal expiratory flow at 25% of the forced capacity [MEF25%], maximal expiratory flow at 50% of the forced capacity [MEF50%], maximal expiratory flow at 75% of the forced capacity [MEF75%] and midexpiratory flow 25%-75% [MEF25%-75%]) were higher than those before treatment (P<0.05), and the pulmonary function in the observation group was higher than that in the control group (P<0.05). After treatment, the serum IgA levels in the two groups were higher than those before treatment (P<0.05), and the serum IgE levels and TCM symptom scores were lower than those before treatment (P<0.05); the serum IgA level in the observation group was higher than that in the control group (P<0.05), and the serum IgE level and TCM symptom score in the observation group were lower than those in the control group (P<0.05). The total effective rate was 94.1% (48/51) in the observation group, which was higher than 88.7% (47/53) in the control group (P<0.05). CONCLUSION: Acupoint thread-embedding combined with fluticasone propionate aerosol could improve the pulmonary function, TCM symptoms and serum IgA and IgE levels in children with chronic persistent bronchial asthma of lung-spleen qi deficiency and spleen-kidney yang deficiency. The curative effect is better than fluticasone propionate aerosol alone. 目的：观察穴位埋线联合丙酸氟替卡松吸入气雾剂治疗儿童慢性持续期支气管哮喘（肺脾气虚型和脾肾阳虚型）的疗效及对肺功能和血清IgA、IgE水平的影响。方法：将120例慢性持续期支气管哮喘患儿随机分为观察组（60例，脱落9例）和对照组（60例，脱落7例），对照组予丙酸氟替卡松吸入气雾剂（每次吸入125μg）治疗，每日2次；观察组在对照组基础上加用穴位埋线，穴取定喘、肺俞、足三里和膻中，每半个月埋线1次，两组均治疗3个月。比较两组患儿治疗前后肺功能指标，血清免疫球蛋白IgA、IgE水平和中医症状积分，并评定临床疗效。结果：治疗后，两组患儿大气道功能指标[呼气峰值流速（PEF）、第1秒用力呼气容积（FEV1）]及小气道功能指标[用力呼气25%流速（MEF25%）、用力呼气50%流速（MEF50%）、用力呼气75%流速（MEF75%）、中段呼气流速（MEF25%~75%）]均较治疗前升高（P<0.05），且观察组高于对照组（P<0.05）。治疗后，两组患儿血清IgA水平较治疗前升高、血清IgE水平和中医症状积分较治疗前降低（P<0.05），且观察组血清IgA水平高于对照组、血清IgE水平和中医症状积分低于对照组（P<0.05）。观察组总有效率为94.1%（48/51），高于对照组的88.7%（47/53，P<0.05）。结论：穴位埋线联合丙酸氟替卡松吸入气雾剂可改善慢性持续期支气管哮喘（肺脾气虚型和脾肾阳虚型）患儿的肺功能、中医症状和血清IgA、IgE水平，疗效优于单纯丙酸氟替卡松吸入气雾剂。.

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