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  • Title: Minoxidil-induced systemic lupus erythematosus.
    Author: Tunkel AR, Shuman M, Popkin M, Seth R, Hoffman B.
    Journal: Arch Intern Med; 1987 Mar; 147(3):599-600. PubMed ID: 3493745.
    Abstract:
    A patient treated for two months with the antihypertensive agent minoxidil developed pleural and pericardial effusions in association with a positive antinuclear antibody titer. No evidence of central nervous system or renal involvement was present, and results of specific tests for idiopathic systemic lupus erythematosus, including anti-double-stranded DNA and anti-Smith antibodies, were negative. Complement levels were normal. The patient's clinical picture improved and titers of antinuclear antibody decreased after discontinuation of minoxidil therapy, suggesting that minoxidil induced a lupus-like syndrome in this patient.
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