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  • Title: Urinary alpha 1 microglobulin levels in surveys of Balkan endemic nephropathy.
    Author: Itoh Y, Cooper EH, Stavlienic A, Cvoriscec D.
    Journal: Biomed Pharmacother; 1986; 40(9):341-4. PubMed ID: 3493813.
    Abstract:
    The urinary alpha 1-microglobulin (alpha 1m) concentration was measured in 644 adults living in districts where Balkan nephropathy (BEN) is endemic. Comparison of alpha 1m with other indicators of tubular proteinuria, which is a classical sign of BEN, showed alpha 1m was a satisfactory marker. Using a cut-off of 20 mg alpha 1m/L none of 102 normal UK residents had a positive level. Whilst a raised level of alpha 1m was present in 85.7% of definitive cases of BEN and in 8.1%, 10.2% and 50% of subjects previously classified as normal, at risk and suspicious respectively according to the criteria used for epidemiological surveys of BEN.
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