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  • Title: [Effect of oxidative metabolism inhibitors on ADH-dependent transport of water in the bladder of Rana temporaria].
    Author: Bagrov IaIu, Manusova NB.
    Journal: Zh Evol Biokhim Fiziol; 1987; 23(1):150-3. PubMed ID: 3494360.
    Abstract:
    It has been demonstrated that inhibitors of oxidative metabolism--rotenone, amytal, antimycin A, oligomycin and 2,4-dinitrophenol--block hydroosmotic response of the urinary bladder of the frog to pituitrin, cAMP and serosal hypertonicity caused by 200 mosm mannitol. Electron donors sodium ascorbate and phenasinemethasulphate completely abolish the inhibitory effect of rotenone and antimycin A (but not of oligomycin). It is concluded that intracellular reactions which are sensitive to the effect of the inhibitors of oxidative metabolism, begin from the step after cAMP formation.
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