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  • Title: In vitro production of granulocyte-macrophage colony-stimulating activity by murine bone marrow and spleen following vinblastine administration in vivo.
    Author: Williams DE, Chervinsky DS, Orsini FR, Tebbi CK, Fitzpatrick JE.
    Journal: Hematol Oncol; 1987; 5(1):35-43. PubMed ID: 3494655.
    Abstract:
    The production of granulocyte-macrophage colony-stimulating activity (CSA) by isolated murine femur shafts, non-dispersed bone marrow and spleens was assessed following administration of Vinblastine (VLB). These organs were removed from 2 h to 10 days post-VLB and allowed to condition endotoxin-free medium for 48 h. CSA activity was assessed using a soft agar cloning system. The data demonstrate that CSA elaboration was maximal 24 h post-VLB, corresponding to the nadir of bone marrow GM-CFC, and 6 h after splenic reached a minimum. No relationship between peripheral blood granulocyte count or serum endotoxin levels were observed.
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