These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Selective Fluoromethyl Couplings of Alkynes via Nickel Catalysis.
    Author: Li H, Wang F, Zhu S, Chu L.
    Journal: Angew Chem Int Ed Engl; 2022 Feb 21; 61(9):e202116725. PubMed ID: 34962343.
    Abstract:
    We describe here a Ni-catalyzed intermolecular carbo-fluoromethylation of alkynes with aliphatic halides and fluoromethyl halides (BrCF2 H and ICH2 F) in the presence of zinc, enabling the facile and selective access to a diverse range of biologically valuable CF2 H/CH2 F-incorporated alkenes with excellent regio- and stereoselectivity. Notably, merging intramolecular radical cyclization with fluoromethyl coupling enables the expedient constructions of CF2 H/CH2 F-incorporated lactones and lactams with high efficiency and selectivity. Mechanistic studies disclose that this catalytic protocol proceeds via a radical addition to an alkyne followed by selective coupling with the fluoromethyl unit.
    [Abstract] [Full Text] [Related] [New Search]