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  • Title: SUBCLINICAL INFLAMMATION IN NON/ALCOHOLIC FATTY LIVER DISEASE AT THE REMOTE PERIOD AFTER THE CHORNOBYL ACCIDENT.
    Author: Nosach OV, Sarkissova EO, Alyokhina SM, Pleskach OY, Litvinets OM, Ovsyannikova LM, Chumak AA.
    Journal: Probl Radiac Med Radiobiol; 2021 Dec; 26():437-448. PubMed ID: 34965565.
    Abstract:
    OBJECTIVE: to evaluate the parameters of inflammatory reaction and oxidative stress in patients with non-alcoholicfatty liver disease (NAFLD) in the remote period after the influence of the Chornobyl accident factors. MATERIALS AND METHODS: Eighty two patients with NAFLD who had been exposed to ionizing radiation as a result ofthe Chornobyl accident and have concomitant cardiovascular pathology were examined. Hematological parametersand the level of highly sensitive C-reactive protein (hsCRP) were determined, and the content of products of oxida-tive modification of lipids and proteins was evaluated. RESULTS: Activation of the processes of oxidative modification of lipids and proteins was observed in most patientswith NAFLD. According to the level of hsCRP, the presence of subclinical inflammation and the risk of developingcomplicated cardiovascular pathology was found in 58 % of patients with NAFLD. The neutrophil / lymphocyte ratiocorrelates positively with hsCRP and can be used as an available routine clinical marker for selection among patientswith NAFLD persons with increased risk of cardiovascular complications. CONCLUSIONS: HsCRP, oxidative modification products of lipids and proteins, ESR, and leukograms should be used toassess the degree of systemic inflammation in people affected by the Chornobyl accident, suffering NAFLD with con-comitant cardiovascular disease. Meta: otsinyty proiavy zapal'noï reaktsiï ta okysliuval'nogo stresu u khvorykh z nealkogol'noiu zhyrovoiu khvo-roboiu pechinky (NAZhKhP) u viddalenomu periodi pislia diï faktoriv Chornobyl's'koï avariï. Materialy i metody. Obstezheno 82 khvorykh z NAZhKhP, iaki zaznaly diï ionizuiuchogo vyprominiuvannia vnaslidokavariï na ChAES ta maiut' suputniu sertsevo-sudynnu patologiiu. Vyznachaly gematologichni pokaznyky ta riven'vysokochutlyvogo S-reaktyvnogo bilka (hsCRP), otsiniuvaly vmist produktiv okysliuval'noï modyfikatsiï lipidivi bilkiv. Rezul'taty. Aktyvatsiia protsesiv okysliuval'noï modyfikatsiï lipidiv i bilkiv sposterigalasia u bil'shosti khvo-rykh z NAZhKhP. Za rivnem hsCRP naiavnist' subklinichnogo zapalennia ta ryzyku rozvytku uskladnenoï sertsevo-sudynnoï patologiï vstanovlena u 58 % khvorykh na NAZhKhP. Spivvidnoshennia neĭtrofily / limfotsyty pozytyv-no koreliuie z hsCRP i mozhe vykorystovuvatysia iak dostupnyĭ rutynnyĭ klinichnyĭ marker dlia vidboru seredkhvorykh z NAZhKhP patsiientiv z pidvyshchenym ryzykom sertsevo-sudynnykh uskladnen'.Vysnovky. V osib, iaki zaznaly vplyvu faktoriv Chornobyl's'koï avariï, pry odnochasnomu perebigu NAZhKhP takhvorob sertsevo-sudynnoï systemy dlia otsinky stupenia systemnogo zapalennia slid vykorystovuvaty pokazny-ky hsCRP, produktiv okysliuval'noï modyfikatsiï lipidiv i bilkiv, ShOE ta leĭkogramy.
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