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Title: INFLUENCE OF RADIOACTIVE BACKGROUND ON SEXUAL FUNCTION IN MEN FROM DIFFERENT REGIONS OF UKRAINE.
Author: Gorpinchenko II, Gurzhenko YM, Spyrydonenko VV.
Journal: Probl Radiac Med Radiobiol; 2021 Dec; 26():479-497. PubMed ID: 34965568.
Abstract:
OBJECTIVE: The article attempts to analyze the nature of sexual dysfunctions in patients living in areas exposed toionizing radiation as a result of the Chornobyl accident. MATERIALS AND METHODS: A study of sexual function was carried out in 186 people (group I) living in the territoriesof Kyiv (Polisske, Chornobyl, Ivankiv, Borodianka, Vyshhorod, Makariv districts) and Zhytomyr (Malyn and Korostendistricts) regions. The control group consisted of persons who were born and lived on the territory of Ivano-Frankivsk and Chernivtsi regions (group II, n = 123). Diagnostics was carried out on an outpatient basis in accor-dance with the standards of the WHO and the Ministry of Health of Ukraine. RESULTS: Analyzing the obtained research results, a significantly larger number of patients with sexual dysfunctionwas identified in group I (82.3 %) than in group II (44.7 %) (р < 0.01). Psychopathological disorders disturbed,respectively, 60.2 % and 41.4 % (p < 0.01). Complaints of decreased libido were presented by 25.8 % of the surveyedmen exposed to ionizing radiation, and 6.5 % of them were concerned about a sharp depression of libido. In groupII patients, this indicator was 14.6 % and 3.3 %, respectively. The integral index of «libido» of the ICEF question-naire revealed a statistically significant difference between the groups (9.23 ± 0.89 and 12.22 ± 1.26, respectively;р < 0.05). In patients exposed to ionizing radiation as a result of the Chornobyl accident, the concentration oftestosterone decreases, and the content of FSH, LH, as well as globulin, which makes sex hormones, increases.Erectile dysfunction in patients of group I was detected in 58.1 % of men, and in patients of group II - 35.0 % (р < 0.01).The difference in the integral indicators of the ICEF questionnaire between the groups was 1.3 times behind the«libido» domain. For other domains - by 1.5-1.6 times. In men living in the territories of Kyiv and Zhytomyr regions,erectile dysfunction occurs earlier and is characterized by a more severe course than in people born and lived in theterritory of Ivano-Frankivsk and Chernivtsi regions. Both in terms of low rates of normal erection (in patients ofgroups I and II, respectively 3.8 % and 13.3 %), and for high percentages of existing moderate/severe ED (respec-tively 71.0 % and 45.5 %), persons from group I are characterized by significantly worse data than persons fromgroup II (р < 0.01). Orgasm pathology was found in 40.3 % of patients in group I and in 25.2 % of patients in groupII (р < 0.01). The quality of life index according to the QoL index in the context of existing sexual disorders in groupI of patients was 4.7 ± 0.4, in patients of group II - 3.9 ± 0.2 (р < 0.05). CONCLUSIONS: The data obtained indicate a tendency for a more significant violation of sexual functions in men whowere born and lived in territories exposed to radioactive contamination as a result of the Chornobyl accident. Meta roboty: provesty analiz kharakteru seksual'nykh dysfunktsiĭ u patsiientiv, iaki meshkaiut' na terytoriiakh, shchozaznaly vplyvu ionizuiuchoï radiatsiï vnaslidok avariï na ChAES.Materialy ta metody. Provedeno doslidzhennia seksual'noï funktsiï u 186 osib (I grupa), iaki meshkaiut' na tery-toriiakh Kyïvs'koï (Polis'kogo, Chornobyl's'kogo, Ivankivs'kogo, Borodians'kogo, Vyshgorods'kogo, Makarivs'kogoraĭoniv) ta Zhytomyrs'koï (Malyns'kyĭ i Korostens'kyĭ raĭony) oblasteĭ. Grupu kontroliu sklaly osoby, iakinarodylysia i meshkaly na terytoriï Ivano-Frankivs'koï ta Chernivets'koï oblasteĭ (II grupa, n = 123). Diagnosty-ka provodylasia na ambulatornomu etapi zgidno zi standartamy VOOZ ta MOZ Ukraïny. Rezul'taty. Analizuiuchy otrymani rezul'taty doslidzhen', bulo vyiavleno virogidno bil'shu kil'kist' patsiientiv izporushenniam seksual'noï funktsiï u I grupi (82,3 %), nizh u II (44,7%) (r < 0,01). Psykhopatologichni porushennia tur-buvaly vidpovidno 60,2 % ta 41,4 % osib (r < 0,01). Skargy na znyzhennia libido pred’iavlialy 25,8 % obstezhenykhcholovikiv, iaki zaznaly vplyvu ionizuiuchoï radiatsiï, z nykh rizke prygnichennia statevogo potiagu turbuvalo 6,5 % osib.U patsiientiv II grupy tseĭ pokaznyk stanovyv vidpovidno 14,6 % ta 3,3 %. Integral'nyĭ pokaznyk «libido» anketyMizhnarodnogo Indeksu Erektyl'noï Funktsiï (MIEF) vyiavyv statystychno dostovirnu riznytsiu mizh grupamy(vidpovidno 9,23 ± 0,89 ta 12,22 ± 1,26; r < 0,05). U patsiientiv, iaki zaznaly vplyvu ionizuiuchoï radiatsiï vnaslidokavariï na ChAES, zmenshuiet'sia seredniĭ pokaznyk testosteronu ta zbil'shuiet'sia vmist FSG, LG, a takozh globulinu,shcho zv’iazuie statevi gormony. Erektyl'na dysfunktsiia u khvorykh I grupy vyiavlena u 58,1 % cholovikiv, a u patsiientivII grupy – u 35,0 % (r < 0,01). Riznytsia integral'nykh pokaznykiv MIEF mizh grupamy stanovyla za domenom «libido»1,3 raza, a za inshymy domenamy – 1,5–1,6 raza. U cholovikiv, iaki meshkaiut' na terytoriiakh Kyïvs'koï ta Zhytomyrs'-koï oblasteĭ, erektyl'na dysfunktsiia vynykaie ranishe i kharakteryzuiet'sia bil'sh tiazhkym perebigom, nizh u osib, iakinarodylysia ta meshkaly na terytoriï Ivano-Frankivs'koï i Chernivets'koï oblasteĭ. Iak za nyz'kymy pokaznykamynormal'noï erektsiï (u patsiientiv I ta II grup vidpovidno 3,8 % ta 13,3 %), tak i za vysokymy vidsotkamy naiavnogoseredn'ogo/tiazhkogo stupenia erektyl'noï dysfunktsiï (vidpovidno 71,0 % ta 45,5 %), osoby z I grupy kharaktery-zuiut'sia virogidno girshymy danymy, nizh osoby z II grupy (r < 0,01). Patologiiu orgazmu bulo vyiavleno u 40,3 %patsiientiv I grupy ta u 25,2 % osib iz II grupy (r < 0,01). Pokaznyk iakosti zhyttia za indeksom QoL, v konteksti na-iavnykh seksual'nykh porushen' u I grupi patsiientiv stanovyv 4,7 ± 0,4, a u khvorykh II grupy – 3,9 ± 0,2 (r < 0,05).Vysnovky. Otrymani dani svidchat' pro tendentsiiu bil'sh znachnogo porushennia seksual'nykh funktsiĭ u cholovikiv,iaki narodylys' ta meshkaly na terytoriiakh, shcho zaznaly radioaktyvnogo zabrudnennia pid chas avariï na ChAES.

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