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  • Title: Spontaneous production of B cell growth factors by SLE lymphocytes.
    Author: Pelton BK, Denman AM.
    Journal: Clin Exp Immunol; 1987 Jan; 67(1):159-66. PubMed ID: 3497742.
    Abstract:
    Systemic lupus erythematosus blood lymphocytes produce B cell growth factors (BCGF) spontaneously to an extent comparable with pokeweed mitogen-stimulated lymphocytes from normal donors. BCGF production by SLE lymphocytes is not increased by PWM and these cells are refractory to exogenous BCGF. Production requires B cells and irradiated T cells but not accessory cells. The properties of spontaneously synthesized BCGF differ in some respects from those induced by PWM. These findings suggest that the abnormal B cell proliferation characteristic of SLE may result, at least in part, from autostimulatory growth factors.
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