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  • Title: Von Willebrand factor fragment in type IIA von Willebrand's disease: demonstration of two different forms of fragments.
    Author: Takahashi H, Tsukada T, Tatewaki W, Hanano M, Sanada M, Shibata A.
    Journal: Haemostasis; 1987; 17(4):182-8. PubMed ID: 3497849.
    Abstract:
    A fast-migrating precipitin peak which showed a reaction of partial immunochemical identity with the major von Willebrand factor (vWf) component was detected by crossed immunoelectrophoresis in agarose gel in plasma but not in platelets from a patient with type IIA von Willebrand's disease (vWD). Another patient undergoing urokinase therapy had a vWf fragment in plasma which was antigenically cross-reactive with the major vWf component. When plasma from both patients was mixed and electrophoresed together in the first dimension, two fast-moving precipitin arcs were demonstrated in the second dimension. These data indicate that two different kinds of vWf fragments can be generated in vivo.
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