These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of macrophage colony-stimulating factor on the function of resident peritoneal macrophages.
    Author: Kanada T, Shikita M, Tsuneoka K, Sakai N, Tomita T, Kanegasaki S.
    Journal: J Pharmacobiodyn; 1987 May; 10(5):215-9. PubMed ID: 3498025.
    Abstract:
    Resident peritoneal cells of monocyte/macrophage lineage were collected by lavage of mice and incubated in vitro for 1-3 d in a culture medium containing various concentrations of macrophage colony-stimulating factor (M-CSF). Stimulation of the cells by zymosan showed that the potency of producing luminol-dependent chemiluminescence had been markedly increased in the CSF-treated cells, indicating increased generation of active oxygen species in these cells. There was an optimal concentration of M-CSF for the enhancement, and the potency of the cells was notably decreased by an overdose of M-CSF. The result was interpreted as being due to the down-regulation of M-CSF receptor.
    [Abstract] [Full Text] [Related] [New Search]