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  • Title: Cephalosporin therapy for childhood meningitis.
    Author: Smith MA, Ryan ME.
    Journal: Am Fam Physician; 1987 Sep; 36(3):185-92. PubMed ID: 3498353.
    Abstract:
    Ampicillin and chloramphenicol have been used for initial empiric therapy of childhood meningitis since the mid-1970s. Problems associated with these drugs include the possibility of chloramphenicol-associated aplastic anemia and the existence of Hemophilus influenzae type b resistance to both ampicillin and chloramphenicol. Several second- and third-generation cephalosporins have been shown to be as effective as ampicillin and chloramphenicol in the treatment of childhood meningitis.
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