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  • Title: Aging influence on the E-rosette forming cells, spontaneous cell mediated cytotoxicity, and antibody dependent cellular cytotoxicity in humans.
    Author: Olinescu A, Hristescu S, Poliopol M, Vasiliu E, Saragea M, Saragea A, Perieteanu R.
    Journal: Arch Immunol Ther Exp (Warsz); 1987; 35(1):1-10. PubMed ID: 3498459.
    Abstract:
    In 131 adults and 107 aging healthy subjects of both sexes, the percentage of the T lymphocytes in peripheral blood and the cytotoxic activities of NK and K cells, were determined. No age-related differences have been found in the number of peripheral blood lymphocytes, the binding of NK cells to the K562 targets, the percentage of E rosette forming cells and the ADCC level. An increased proportion of T suppressor lymphocytes in elderly subjects and a large inter- and intra-individual variation of NK cells activity in both adult and aged subjects were found.
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