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  • Title: Synthesis and pharmacological properties of benzothienothiadiazolopyrimidine derivatives. III.
    Author: Russo F, Santagati A, Santagati M, Caruso A, Trombadore S, Amico-Roxas M.
    Journal: Farmaco Sci; 1987 Jun; 42(6):437-47. PubMed ID: 3498650.
    Abstract:
    2-Substituted derivatives of 5H-benzothieno [3,2-d] [1,3,4]-thiadiazolo [3,2-a]pyrimidin-5-one and of 10H-benzothieno [2,3-d] [1,3,4]-thiadiazolo [3,2-a]pyrimidin-10-one have been synthesized. The analgesic, antiinflammatory and ulcerogenic activities of these derivatives were evaluated. Some derivatives showed an analgesic activity similar to or a little lower than that of indomethacin, and much higher than that of mefenamic acid, acetylsalicyclic acid and phenylbutazone, with a lower acute toxicity and a better gastric tolerance.
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