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  • Title: Ca2+ uptake and IP3-induced Ca2+ release in permeabilized human lymphocytes.
    Author: Eberl G, Schnell K.
    Journal: FEBS Lett; 1987 Oct 05; 222(2):349-52. PubMed ID: 3498653.
    Abstract:
    The 45Ca2+ uptake and 45Ca2+ release in saponin-permeabilized human lymphocytes were studied. An ATP-dependent Ca2+ uptake into a nonmitochondrial, intracellular Ca2+ store is observed which is approx. 2 orders of magnitude greater than the ATP-independent Ca2+ uptake. The Ca2+ uptake is inhibited by vanadate, but it is insensitive to oligomycin and ruthenium red. IP3 induces dose-dependent 45Ca2+ release. For half-maximum Ca2+ release 0.25-0.5 microM IP3 is required. The results of our studies suggest that 45Ca2+ is predominantly stored within the endoplasmic reticulum of the lymphocytes.
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