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Title: Evaluation of 5-hydroxytryptophan administration as a test of pineal function in humans. Author: Cavallo A, Richards GE, Meyer WJ, Waldrop RD. Journal: Horm Res; 1987; 27(2):69-73. PubMed ID: 3498672. Abstract: We tested the hypothesis that acute 5-hydroxytryptophan (5-HTP) administration would cause an increase in concentrations of plasma melatonin to levels observed during the spontaneous nocturnal melatonin surge. We administered 5-HTP orally (5-12 mg/kg) to 10 healthy children and 5 healthy adults, and measured melatonin concentrations in plasma samples obtained every 30 min for 3-6 h. There was no appreciable increase in melatonin after 5-HTP stimulation, even though a melatonin increase has been reported in sheep treated with 5-HTP.[Abstract] [Full Text] [Related] [New Search]