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  • Title: Fibrillar ultrastructure of the glomerular basement membrane of the rat kidney as revealed by digestive treatment.
    Author: Ichiyasu A, Takaoka M, Makino H, Takahashi K, Ota Z.
    Journal: Acta Med Okayama; 1987 Aug; 41(4):183-5. PubMed ID: 3499055.
    Abstract:
    Rat kidney glomerular basement membrane (GBM) was isolated and digested with alpha-amylase and elastase. Electron microscopy revealed a meshwork structure composed of fibrils 3 nm in width. They appeared to be type IV collagen fibrils. We succeeded in clarifying a significant ultrastructural aspect of the GBM which had been unclear until now. The findings are consistent with our previously proposed GBM molecular sieve theory.
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