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  • Title: HLA and multiple sclerosis in south east Wales.
    Author: Swingler RJ, Kirk PF, Darke C, Compston DA.
    Journal: J Neurol Neurosurg Psychiatry; 1987 Sep; 50(9):1153-5. PubMed ID: 3499485.
    Abstract:
    A stronger association has been found between multiple sclerosis and HLA-DR2 than -DQwl in south east Wales (prevalence c 113/10(5)) in contrast to recent observations in north east Scotland (prevalence 178/10(5). The complex relationship between the HLA system and multiple sclerosis, demonstrated in this and other studies, is explained more easily under a polygenic model of inheritance, in which environmental events and genes interact, than by the presence of a single susceptibility gene.
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