These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Changes in the antigenic phenotype of mouse thymocytes after exposure to chemical inducers of differentiation and ionizing radiation].
    Author: Sorokina NI, Miroshnichenko IV, Nikonova MF, Aknazarova RKh, Mikhna MG.
    Journal: Radiobiologiia; 1987; 27(5):581-5. PubMed ID: 3499625.
    Abstract:
    Irradiation of a mouse thymocyte fraction enriched by T-lymphocyte precursors changes the antigenic phenotype of cells toward the increase of their highly differentiated forms. Similar changes in membrane marker antigens are produced by chemical inductors of differentiation and thymotropin. The changes in the cell phenotype induced by the above agents are associated with both membrane and intragenome rearrangements. The results of the experiments on preventing the expression of some antigens by puromycin and the data on the level of spontaneous genome lesions in thymocyte fractions have prompted an assumption that destabilization of the genome upon irradiation increases DNA injury above some critical level which may serve a stimulus for "sorting out" the most radiosensitive thymocyte fraction.
    [Abstract] [Full Text] [Related] [New Search]