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  • Title: [Role of hydrophobic elements of the plasma membrane in the reaction of frog urinary bladder cells to antidiuretic hormones].
    Author: Natochin IuV, Shakhmatova EI, Bakosh P.
    Journal: Biull Eksp Biol Med; 1987 Nov; 104(11):528-31. PubMed ID: 3499940.
    Abstract:
    The addition of 10 mg/ml triton X-100 to Ringer solution within the bladder near the serous membrane increases water permeability of the frog bladder wall. At a concentration of 0.1 mg/ml it gives no visible effect on the water and sodium permeability, but inhibits the effects of ADH, forskolin and cAMP. Changes in plasma membrane hydrophobic properties due to the addition of triton X-100 are reversible and ADH effect can be restored after the detergent is removed from the solution. The results obtained show that hydrophobic groups of the plasma membrane contribute to increased water permeability in response to ADH.
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