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  • Title: Idiotypic network in myasthenia gravis demonstrated by human monoclonal B-cell lines.
    Author: Lefvert AK, Holm G.
    Journal: Scand J Immunol; 1987 Nov; 26(5):573-8. PubMed ID: 3500505.
    Abstract:
    Human monoclonal anti-receptor and anti-idiotypic antibodies were obtained from Epstein-Barr virus-transformed lymphoblastoid cells of patients with myasthenia gravis. The majority of antibodies (85/117) were IgM, and all IgM antibodies had lambda light chains. A marked restriction to one recurrent idiotype was found, despite the additional presence of other idiotypes in the serum from all patients. The presence of idiotypes and anti-idiotypes in the same patient was verified by the demonstration of specific complex formation between an anti-receptor antibody and an anti-idiotypic antibody produced by two different clones. Studies of human monoclonal antibodies produced by lymphoblastoid cell lines provide important information about the B-cell repertoire in myasthenia gravis and demonstrate a basis for a functional antibody network in this disease.
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