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  • Title: Accommodation of rat nigrostriatal dopamine neurones to high frequency electrical stimulation of the median forebrain bundle: in vivo voltammetric data.
    Author: Stamford JA, Kruk ZL, Millar J.
    Journal: Neurosci Lett; 1987 Nov 23; 82(2):172-6. PubMed ID: 3501081.
    Abstract:
    The frequency response of nigrostriatal neurones to electrical stimulation of the median forebrain bundle was investigated in vivo using high-speed cyclic voltammetry to measure the evoked striatal dopamine overflow. It was found that the nerves could follow 25-50 Hz stimulation for at least 10 s, whereas the neurones were unable to respond to high frequencies (100-200 Hz) for more than 1-3 s. Accommodation, due to incomplete re-equilibration of ionic fluxes between successive stimuli, provides a possible explanation for these findings.
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