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  • Title: Triradial configurations indicate that expression of the fragile site at Xq27 is non-lethal.
    Author: Tommerup N.
    Journal: Ann Genet; 1987; 30(4):231-2. PubMed ID: 3501266.
    Abstract:
    The staining pattern of BUdR-substituted sister chromatids in triradial configurations associated with the fragile site at Xq27 is reported. The pattern observed in 2nd- and 3rd-generation cells is compatible with the hypothesis that the triradial configurations are caused by mitotic non-disjunction of the distal fragment in the previous mitotic division. This in turn indicates that cells can survive expression of the fragile site in a previous cell cycle.
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