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  • Title: Changes in intraocular pressure associated with the administration of propofol.
    Author: Vanacker B, Dekegel D, Dionys J, Garcia R, Van Eeckhoutte L, Dralants G, Van de Walle J.
    Journal: Br J Anaesth; 1987 Dec; 59(12):1514-7. PubMed ID: 3501305.
    Abstract:
    The effect of propofol on intraocular pressure (IOP) was measured in 25 patients presenting for elective non-ophthalmological surgery when propofol was used for the induction and maintenance of anaesthesia (together with 67% nitrous oxide in oxygen, and vecuronium). Normocapnia was maintained. After induction of anaesthesia, intraocular pressure was significantly lower than the baseline value; during maintenance IOP never exceeded the preinduction value. There was a temporary decrease in arterial pressure after induction. In nine patients a cutaneous flush was observed and in seven patients there was discomfort on injection. Spontaneous movement in 20% and hiccup in 12% of the patients were observed at the time of tracheal intubation.
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