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  • Title: 3D Flower-like NiCo Layered Double Hydroxides: An Efficient Electrocatalyst for Non-Enzymatic Electrochemical Biosensing of Hydrogen Peroxide in Live Cells and Glucose in Biofluids.
    Author: Annalakshmi M, Kumaravel S, Chen TW, Chen SM, Lou BS.
    Journal: ACS Appl Bio Mater; 2021 Apr 19; 4(4):3203-3213. PubMed ID: 35014407.
    Abstract:
    Herein, a hierarchical structure of flower-like NiCo layered double hydroxides (NiCo LDH) microspheres composed of three-dimensional (3D) ultrathin nanosheets was successfully synthesized via a facile hydrothermal approach. The formation of NiCo LDH was confirmed by various physicochemical studies, and the NiCo LDH-modified glassy carbon electrode was used as an efficient dual-functional electrocatalyst for non-enzymatic glucose and hydrogen peroxide (H2O2) biosensor. The host matrix of hydrotalcite NiCo LDH exhibits the enhanced electrocatalytic sensing performances with a quick response time (<3 s), wide linear range (50 nM-18.95 mM and 20 nM-11.5 mM) and lowest detection limits (S/N = 3) (10.6 and 4.4 nM) toward glucose and H2O2, and also it exhibits good stability, selectivity, and reproducibility. In addition, this biosensor was successfully utilized to the real-time detection of endogenous H2O2 produced from live cells and glucose in various biological fluids, and demonstrates that the as synthesized NiCo LDH may provide a successful pathway for physiological and clinical pathological diagnosis.
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