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  • Title: [Analysis of the association between previous contraceptive use and the incidence of cervico-uterine cancer in women from the northern and eastern area of Santiago].
    Author: Dabancens A, López J, Molina R, Thomas DB.
    Journal: Rev Chil Obstet Ginecol; 1986; 51(2):188-94. PubMed ID: 3503347.
    Abstract:
    The case-control method was used to analyze records of 85 women with cervical cancer detected by screening in the northern area of Santiago, Chile, to assess a possible relationship of oral contraceptive (OC) use and cervical cancer. Epidemiologic methods used to assess the association between OCs and cervical cancer were 1st described. Several of the cohort studies failed to provide adequate controls or to take into account the factor of sexual promiscuity. Most of the case control studies found no risk or a slight increase in risk; the study finding the greatest relative risk had inadequate controls. In the present study, 4 controls were sought for each case matched by age, parity, year of examination, and number of previous cytological examinations. The average age was 45.18 for the 85 cases and 44.28 for the 268 controls. The average parity was 3.73 for cases and 3.72 for controls. The average number of previous examinations was 3.46 for cases and 5.79 for controls. At the time of the examinations, 6 cases and 14 controls used OCs, no cases and 1 control used injectables, 24 cases and 118 controls used IUDs, 5 cases and 13 controls used other methods, and 51 cases and 117 controls used no method. No increase in the relative risk of developing cervical cancer was detected among OC users.
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