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  • Title: A visible and near-infrared light dual responsive "signal-off" and "signal-on" photoelectrochemical aptasensor for prostate-specific antigen.
    Author: Tang X, Lu C, Xu X, Ding Z, Li H, Zhang H, Wang Y, Li C.
    Journal: Biosens Bioelectron; 2022 Apr 15; 202():113905. PubMed ID: 35033829.
    Abstract:
    A visible and near-infrared light dual responsive "signal-off" and "signal-on" photoelectrochemical aptasensor was constructed for determining prostate-specific antigen (PSA) based on MoS2 nanoflowers and gold nanobipyramids. The dual responsive photoelectrochemical aptasensor can provide accurate results for PSA determination. For the photoelectrochemical aptasensor fabrication, amino-group functionalized aptamers were immobilized on a MoS2 nanoflowers modified glassy carbon electrode surface for the specific recognition, and thus to achieve a "signal-off" aptasensor for PSA under visible light illumination. Subsequently, gold nanobipyramids integrated with thiol-functional aptamer were introduced to the "signal-off" aptasensing interface after PSA recognition. Under excitation with near-infrared light at 808 nm, the photocurrent response can be amplified significantly due to the excellent conductivity and local surface plasmon resonance effect of gold nanobipyramids, thus to producing a "signal-on" model for determining PSA. Under the optimized conditions, the dual-responsive photoelectrochemical aptasensor shows a linear response to the logarithm of PSA concentration in the range of 0.005-100 ng/mL. The detection limits for PSA determination with a "signal-off" or a "signal-on" mode are 1.75 pg mL-1 and 0.39 pg mL-1, respectively. The dual-responsive photoelectrochemical aptasensor was also employed for determining PSA in clinical serum samples with satisfactory selectivity and excellent accuracy.
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