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  • Title: Three new cassane-type diterpenoids from Caesalpinia sinensis.
    Author: Chen YK, Fan MY, Zhang YM, Zhang PZ, Shu RG.
    Journal: J Asian Nat Prod Res; 2022 Dec; 24(12):1134-1140. PubMed ID: 35037543.
    Abstract:
    Three new cassane-type diterpenoids, namely, (4S)-6β,12α,19-trihydroxy-cass-13(15)-en-16,12-olide (1), cass-13(15)-en-​16,12-olide (2), and 12α-hydroxy-cass-13(15)-en-16,12-olide (3), were isolated from the seeds of Caesalpinia sinensis. The structures of 1-3 were established by extensive spectroscopic analysis, and their absolute configurations were assigned by electronic circular dichroism (ECD) calculations. The inhibitory activities against PTP1B of the isolated compounds were evaluated. The results showed that compound 2 possessed PTP1B inhibitory activity with an IC50 value of 217.45 ± 36.4 μM.
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