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  • Title: Effect of repeated administration of antidepressant drugs on the serum and brain concentration of testosterone and its metabolites.
    Author: Przegaliński E, Warchoł-Kania A, Budziszewska B, Jaworska L.
    Journal: Pol J Pharmacol Pharm; 1987; 39(6):683-9. PubMed ID: 3503989.
    Abstract:
    A repeated oral treatment (twice daily, for 21 consecutive days) with 10 mg/kg of antidepressants imipramine, amitriptyline, citalopram, mianserin affects the level of testosterone and its metabolites (5 alpha-dihydrotestosterone and estradiol-17 beta) in the serum and brain structures (cerebral cortex, hypothalamus). Citalopram and mianserin increased significantly the serum testosterone concentration, while imipramine and amitriptyline reduced the concentration of 5 alpha-dihydrotestosterone. In the cerebral cortex a reduction in 5 alpha-dihydrotestosterone after imipramine, and in the hypothalamus a decrease in testosterone level after amitriptyline were observed. None of the investigated drugs influenced estradiol-17 beta concentration in the serum or in the brain.
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