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  • Title: Bimetallic Palladium/Cobalt Catalysis for Enantioselective Allylic C-H Alkylation via a Transient Chiral Nucleophile Strategy.
    Author: Wang H, Xu Y, Zhang F, Liu Y, Feng X.
    Journal: Angew Chem Int Ed Engl; 2022 Mar 14; 61(12):e202115715. PubMed ID: 35040550.
    Abstract:
    An asymmetric allylic C-H functionalization has been developed by making use of transient chiral nucleophiles, as well as bimetallic synergistic catalysis with an achiral Pd0 catalyst and a chiral N,N'-dioxide-CoII complex. A variety of β-ketoesters and N-Boc oxindoles coupled with allylbenzenes and aliphatic terminal alkenes were well tolerated, furnishing the desired allylic alkylation products in high yields (up to 99 %) with excellent regioselectivities and enantioselectivities (up to 99 % ee).
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