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Title: [Characteristics of Sleep Electroencephalographic Power in Chronic Insomnia Patients].
Author: Shi Y, Ren R, Zhang Y, Zhang HP, Tan L, Zhou JY, Sun YF, Li TM, Tang XD.
Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2022 Jan; 53(1):149-153. PubMed ID: 35048616.
Abstract:
OBJECTIVE: To study the sleep electroencephalogram (EEG) power features of patients with chronic insomnia. METHODS: Retrospective analysis was performed with patients who met the ICD-10 diagnostic criteria for chronic insomnia, using polysomnography (PSG) to examine the overnight sleep EEG. The sleep architectures and relative EEG power across five frequency bands during overnight sleep were compared to study the differences between the insomnia and control groups. Furthermore, the correlation between EEG power and various PSG measures was also analyzed. RESULTS: Forty-five subjects were enrolled in the study, including 25 chronic insomniacs (18 females, aged [36.2±10.7] years) and 20 controls (18 females, aged [36.1±7.6] years). Compared to those of the control group, insomnia patients had significantly lower value of delta power ([38.0±6.1] vs. [43.2±5.8], P<0.05) in the NREM1 stage, and increased value of beta power during total NREM, NREM1 and NREM2 (NREM sleep [5.4±2.3] vs. [3.8±1.4], NREM1 [11.3±3.5] vs. [8.7±2.8], and NREM2 [5.7±2.3] vs. [4.4±1.4], all P<0.05). For correlation analyses, in the insomnia group, a significantly positive correlation was found between the delta value during NREM sleep and the duration of NREM3 sleep ( r=0.527). The beta value during NREM sleep was found to be negatively correlated to the duration of NREM3 sleep ( r=－0.767). A positive correlation was found between the beta value during NREM sleep and the duration of NREM1 and NREM2 sleep ( r=0.486 and 0.589, respectively). CONCLUSION: The results suggest that patients with chronic insomnia have decreased low-frequency EEG power, but increased high-frequency EEG power during NREM sleep. The findings indicate that cortex arousal level is elevated in chronic insomniacs during NREM sleep. 目的: 探讨慢性失眠患者的睡眠脑电功率特征。方法: 回顾性分析符合ICD-10慢性失眠诊断标准并完成整夜多导睡眠监测（PSG）患者的睡眠脑电资料。比较失眠组和对照组睡眠结构及不同睡眠分期相对脑电功率特征的差异，并进一步分析脑电功率值与不同PSG指标的相关性。结果: 共计纳入45例研究对象，其中失眠患者25例（女性18例），年龄（36.2±10.7）岁；对照组20例（女性18例），年龄（36.1±7.6）岁。与对照组相比，失眠组患者NREM1期delta功率降低〔（38.0±6.1） vs. （43.2±5.8），P<0.05〕；NREM期及NREM1期、NREM2期beta功率增高〔NREM期：（5.4±2.3） vs. （3.8±1.4）；NREM1期：（11.3±3.5） vs. （8.7±2.8）；NREM2期：（5.7±2.3） vs. （4.4±1.4）；P均<0.05〕。同时，失眠组患者NREM期delta功率与NREM3期睡眠时间呈正相关(r=0.527)。NREM期beta功率与NREM3期睡眠时间呈负相关(r=−0.767)，与NREM1期、NREM2期睡眠时间呈正相关(r=0.486、0.589)。结论: 慢性失眠患者夜间NREM期睡眠中低频脑电功率减少，高频脑电功率增加，研究结果提示慢性失眠患者NREM期睡眠过程中大脑皮质觉醒水平增高。

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