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  • Title: 'Patient failure' as a reliability model for the 'minipill': a clinical study.
    Author: Nummi S.
    Journal: Curr Med Res Opin; 1978; 5(5):406-11. PubMed ID: 350492.
    Abstract:
    A trial was carried out in 10 healthy women to study the effects of withdrawal of treatment with 0.5 mg lynestrenol per day, for 3 successive days during the pre-ovulatory phase, on the physiological properties of the cervical mucus, vaginal cytology and pituitary and ovarian functions. In most cases, the amount, Spinnbarkeit and ferning of the cervical mucus and sperm penetration remained the same as that before interruption of treatment. In 2 women, the ferning altered to 'good' for 2 to 3 days as the amount of mucus increased slightly. Spinnbarkeit increased at the same time and sperm penetration was good. The changes in LH and FSH excretion suggested that ovulation possibly took place in 1 of the women studied. A mid-cycle oestrogen peak was seen in 2 women. No side-effects were reported during the study apart from irregular intermenstrual bleeding in 1 woman. Patient failure as a reliability model for the minipill is discussed. .5 mg lynestrenol/day was withdrawn from 10 healthy women for 3 successive days during the preovulatory phase to study the effects of withdrawal on the physiological properties of the cervical mucus, vaginal cytology, and pituitary and ovarian functions. In most cases there was no change. However, in 2 women the ferning altered to good for 2-3 days and the amount of mucus increased slightly. Spinnbarkeit also increased and sperm penetration was good. The changes in luteinizing hormone and follicle stimulating hormone excretion indicated that ovulation possibly took place in 1 of the women. A midcycle estrogen peak was seen in 2 of the women. Irregular intermenstrual bleeding in 1 woman was the only side effect reported.
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