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  • Title: [Drug noxae as indications for pregnancy interruption].
    Author: Neubert D.
    Journal: Internist (Berl); 1978 May; 19(5):304-9. PubMed ID: 350801.
    Abstract:
    Factors are discussed which are important in determining whether use of a substance with a known or suspected teratogenic effect can be considered an indication for induced abortion. In some cases, the fetal membranes can compensate for damage done during embryonic development. Not only the type of substance is important; the teratogenic effect of various compounds is dose-dependent. A risk of spontaneous fetal abnormality is present in every pregnancy; no substance is known which causes such abnormalities in 100% of the cases. In order to determine whether a substance actually has teratogenic effects, an epidemiological study must be very large. A list of several commonly prescribed substances and the risk of teratogenic effects associated with them is presented. Use of teratogenic substances can be considered as an indication for abortion only if the dosage, the length of use, the stage of pregnancy in which the substance is taken, the psychological status of the mother, and other factors are considered. The mother should decide for herself if the risk of a fetal abnormality is acceptable to her.
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