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  • Title: [The role of the cholinergic system in the regulation of blood flow through the reproductive organs of swine during the estrous cycle].
    Author: Dynarowicz I, Dziegielewski M.
    Journal: Pol Arch Weter; 1987; 27(4):69-83. PubMed ID: 3508521.
    Abstract:
    The flow in uterine artery (ua) and ovarian artery (oa) of isolated reproductive organs of sows (100-130 kg/head) perfounded with animal own blood and Krebs-Henseleit fluid at the constant pressure of 100 mm Hg was measured. Together with measuring the flow, the tension of the smooth muscle of organ was controlled. Applying acetylocholine (ACh), atropine (A), hexamethonium (H) and phentolamine (F) the analysis of the functions of muscarine (M) and nicotine (N) receptors of the cholinergic system in regulation of blood flow through the reproductive organs during the oestrous cycle was carried out. It was found that application of 0.3 microgram ACh into ua, and 0.5 microgram ACh into oa causes slight increase in the blood flow. Application of ACh in doses of 1 microgram into these vessels causes decrease of the flow and increase in tension and motorics of the organ. A eliminates the influence of ACh upon the tension and motorics of the studied organ and potencializes the decreasing influence of ACh applied in the dose of 1 microgram upon the blood flow. A decreases the flow limiting action of 1 microgram ACh upon the flow, and also eliminates the effect of decrease of flow caused by application of 1 microgram ACh after A. H potencializes the influence of small doses of ACh increasing the flow in ua and oa, but does not influence the flow limiting and tension increasing action of 1 microgram dose of ACh. Both A and H in doses applied cause increase in blood flow in the vessel areas under study. The results of the research indicate that changes in the blood flow through the areas under investigation induced by application of ACh are the resultant of three factors. 1. The vasodilatative effect resulting from the stimulation of the receptor M. 2. Stimulation of the cholinergic receptor N and connected with it freeing catecholamines responsible for the tension of vessels and contraction of smooth muscles of the organ. 3. Pressing influence upon the vessels of contracting smooth muscles connected with stimulation of M and N receptors. The sensitivity of vessels in the oa area to M-cholinergic stimulation is lower than that in the ua artery and it is higher in the luteal phase than in pre- and post-ovulation phases in both vessel areas. The magnitude of nicotine reaction of endogenous catecholamines freeing does not undergo significant changes during the oestrous cycle.
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