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  • Title: Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics.
    Author: Stütz A, Georgopoulos A, Granitzer W, Petranyi G, Berney D.
    Journal: J Med Chem; 1986 Jan; 29(1):112-25. PubMed ID: 3510297.
    Abstract:
    Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.
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